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Handbook of Materials for Nanomedicine

SYSNO ASEP	0351235
Document Type	M - Monograph Chapter
R&D Document Type	Monograph Chapter
Title	Synthetic polymer-drug conjugates for human therapy
Author(s)	Ulbrich, Karel (UMCH-V)_RID Šubr, Vladimír (UMCH-V)_{RID, ORCID}
Source Title	Handbook of Materials for Nanomedicine. - Singapore : Pan Stanford Publishing Pte Ltd, 2010 / Torchilin V. ; Amiji M. M. - ISBN 978-981-4267-55-7
Pages	s. 5-79
Number of pages	75 s.
Number of pages	840
Language	eng - English
Country	SG - Singapore
Keywords	drug delivery ; polymer-drug conjugates ; drug targeting
Subject RIV	CD - Macromolecular Chemistry
R&D Projects	IAAX00500803 GA AV ČR - Academy of Sciences of the Czech Republic (AV ČR)
CEZ	AV0Z40500505 - UMCH-V (2005-2011)
UT WOS	000292544400002
Annotation	Polymer-drug conjugates represent a novel generation of polymer therapeutics enabling site-specific drug action what predestines them predominantly for tumor therapy. In this review a design, synthesis and physico-chemical and biological properties of water-soluble synthetic polymer-drug conjugates including principles of tumor-specific passive and tumor cell-specific active targeting, controlled drug release and elimination of the polymer drug carrier from organism is discussed and potential of polymer-drug conjugates for tumor treatment is evaluated.
Workplace	Institute of Macromolecular Chemistry
Contact	Eva Čechová, cechova@imc.cas.cz ; Tel.: 296 809 358
Year of Publishing	2011

Number of the records: 1