Number of the records: 1

Negative regulation of Wnt signaling mediated by CK1-phosphorylated Dishevelled via Ror2

SYSNO ASEP	0351205
Document Type	J - Journal Article
R&D Document Type	Journal Article
Subsidiary J	Článek ve WOS
Title	Negative regulation of Wnt signaling mediated by CK1-phosphorylated Dishevelled via Ror2
Author(s)	Witte, F. (DE) Bernatík, O. (CZ) Kirchner, K. (DE) Mašek, J. (CZ) Mahl, A. (DE) Krejčí, P. (CZ) Mundlos, S. (DE) Schambony, A. (DE) Bryja, Vítězslav (BFU-R)_{RID, ORCID} Stricker, S. (DE)
Number of authors	10
Source Title	FASEB Journal. - : Wiley - ISSN 0892-6638 Roč. 24, č. 7 (2010), s. 2417-2426
Number of pages	10 s.
Language	eng - English
Country	US - United States
Keywords	Wnt/beta-catenin signaling ; casein kinase ; Ror2
Subject RIV	BO - Biophysics
R&D Projects	GC204/09/J030 GA ČR - Czech Science Foundation (CSF)
CEZ	AV0Z50040507 - BFU-R (2005-2011)
	AV0Z50040702 - BFU-R (2007-2013)
UT WOS	000279343600028
DOI	10.1096/fj.09-150615
Annotation	Dishevelled (Dvl) is a multifunctional effector of different Wnt cascades. We provide evidence that Dvl phosphorylated by casein kinase 1 epsilon can bind atypical receptor kinase Ror2. We show that CK1-phosphorylated Dvl induced by both canonical and non-canonical Wnt ligands triggers negative feedback regulation in a Ror2-dependent manner.
Workplace	Institute of Biophysics
Contact	Jana Poláková, polakova@ibp.cz, Tel.: 541 517 244
Year of Publishing	2011

Number of the records: 1