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Tumour necrosis is a postoperative prognostic marker for pancreatic cancer patients with a high interobserver reproducibility in histological evaluation
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SYSNO ASEP 0350954 Document Type J - Journal Article R&D Document Type Journal Article Subsidiary J Článek ve WOS Title Tumour necrosis is a postoperative prognostic marker for pancreatic cancer patients with a high interobserver reproducibility in histological evaluation Author(s) Hiraoka, N. (JP)
Ino, Y. (JP)
Sekine, S. (JP)
Tsuda, H. (JP)
Shimada, K. (JP)
Kosuge, T. (JP)
Závada, Jan (UOCHB-X)
Yoshida, M. (JP)
Yamada, K. (JP)
Koyama, T. (JP)
Kanai, Y. (JP)Number of authors 11 Source Title British Journal of Cancer. - : Springer - ISSN 0007-0920
Roč. 103, č. 7 (2010), s. 1057-1065Number of pages 9 s. Language eng - English Country GB - United Kingdom Keywords pancreatic cancer ; hypoxia ; prognostics Subject RIV EB - Genetics ; Molecular Biology CEZ AV0Z40550506 - UOCHB-X (2005-2011) UT WOS 000282222000018 DOI 10.1038/sj.bjc.6605854 Annotation Hypoxia is a major factor of increased invasivity of cancer, resulting in a poor prognosis. In tumor sections, it is manifested by necrotic foci and expression of CAIX protein. We investigated 248 patients with pancreatic ductal carcinoma and correlated necrosis and CAIX with the lenght of survival. SAIX is a biomarker which can easily be evaluated by independent scientists. Workplace Institute of Organic Chemistry and Biochemistry Contact asep@uochb.cas.cz ; Kateřina Šperková, Tel.: 232 002 584 ; Viktorie Chládková, Tel.: 232 002 434 Year of Publishing 2011
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