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Nanostructured complexes of polyelectrolytes and charged polypeptides
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SYSNO ASEP 0350917 Document Type J - Journal Article R&D Document Type Journal Article Subsidiary J Článek ve WOS Title Nanostructured complexes of polyelectrolytes and charged polypeptides Author(s) Müller, M. (DE)
Ouyang, W. (DE)
Bohatá, Karolína (UMCH-V)
Kessler, B. (DE)Source Title Advanced Engineering Materials. - : Wiley - ISSN 1438-1656
Roč. 12, Sp. Iss. 9 (2010), B519-B528Number of pages 10 s. Action Sino-German Symposium on Advanced Biomedical Nanostructures /1./ Event date 26.10.2009-30.10.2009 VEvent location Jena Country DE - Germany Event type WRD Language eng - English Country DE - Germany Keywords situ ATR-FTIR ; alpha-helical polypeptides ; multilayer films Subject RIV CD - Macromolecular Chemistry CEZ AV0Z40500505 - UMCH-V (2005-2011) UT WOS 000283996400014 DOI 10.1002/adem.201080005 Annotation Nanoparticles and films of complexes between polyelectrolytes (PELs) and oppositely charged polypeptides emphasizing the influence of PEL molecular stiffness on the generated nanostructures are reported. Homopolypeptides like cationic poly(L-lysine) (PLL) and anionic poly(L-glutamic acid) (PLG) were used, whose conformations can be changed from random coil to α-helix by salt type or pH value. Randomly coiled PLL caused spherical PEC particles and isotropically structured PEM films. For PEM films consisting of PDADMAC/PLG PLG terminating PEM-6 was proteininert, while PDADMAC terminating PEM-7 was proteinactive. PEM films consisting of PDL/PSS showed higher enantiospecific adsorption of α-helical myoglobin compared to PLL/PSS. These nanoparticles and films are envisioned as bioinert and bioactive material substrates, unidirectional cell growth, polymer/cell scaffolds, and nanocarriers. Workplace Institute of Macromolecular Chemistry Contact Eva Čechová, cechova@imc.cas.cz ; Tel.: 296 809 358 Year of Publishing 2011
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