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Time-resolved FRET between GPCR ligands reveals oligomers in native tissues
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SYSNO ASEP 0350688 Document Type J - Journal Article R&D Document Type Journal Article Subsidiary J Článek ve WOS Title Time-resolved FRET between GPCR ligands reveals oligomers in native tissues Author(s) Albizu, L. (FR)
Cottet, M. (FR)
Králíková, Michaela (UEM-P) RID
Stoev, S. (US)
Steyer, R. (FR)
Brabet, I. (FR)
Roux, T. (FR)
Bazin, H. (FR)
Bourrier, E. (FR)
Lamarque, L. (FR)
Breton, C. (FR)
Rives, M. L. (US)
Newman, A. H. (US)
Javitch, J. A. (US)
Trinquet, E. (FR)
Manning, M. (US)
Pin, J. P. (FR)
Mouillac, B. (FR)
Durroux, T. (FR)Source Title Nature Chemical Biology . - : Nature Publishing Group - ISSN 1552-4450
Roč. 6, č. 8 (2010), s. 587-594Number of pages 8 s. Language eng - English Country US - United States Keywords G protein-coupled receptor ; FRET Subject RIV EB - Genetics ; Molecular Biology CEZ AV0Z50390512 - UEM-P (2005-2011) UT WOS 000280096600009 DOI 10.1038/NCHEMBIO.396 Annotation The artical "Time-resolved FRET between GPCR ligands reveals oligomers in native tissues" shows for the first time that G-protein coupled receptors (GPCRs) form oligomeric complexes also in native tissues and not only in heterologous expression systems. Oligomerization of these receptors regulates their function and pharmacological properties and thus influences all the processes controled by GPCRs that are involved in the cell response to extracellular stimuli. Workplace Institute of Experimental Medicine Contact Lenka Koželská, lenka.kozelska@iem.cas.cz, Tel.: 241 062 218, 296 442 218 Year of Publishing 2011
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