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Ionotropic NMDA and P2X1/5 receptors mediate synaptically induced Ca2+ signalling in cortical astrocytes
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SYSNO ASEP 0350431 Document Type J - Journal Article R&D Document Type Journal Article Subsidiary J Článek ve WOS Title Ionotropic NMDA and P2X1/5 receptors mediate synaptically induced Ca2+ signalling in cortical astrocytes Author(s) Palygin, O. (US)
Lalo, U. (GB)
Verkhratsky, Alexei (UEM-P)
Pankratov, Y. (GB)Source Title Cell Calcium. - : Elsevier - ISSN 0143-4160
Roč. 48, č. 4 (2010), s. 225-231Number of pages 7 s. Language eng - English Country DE - Germany Keywords Astroglia ; Ca2+ signalling ; NMDA receptors Subject RIV FH - Neurology R&D Projects GA305/08/1384 GA ČR - Czech Science Foundation (CSF) CEZ AV0Z50390703 - UEM-P (2007-2013) UT WOS 000284659100006 EID SCOPUS 77958155140 DOI 10.1016/j.ceca.2010.09.004 Annotation These results demonstrate that activation of astroglial ionotropic NMDA and P2X1/5 receptors increases intracellular free calcium in cortical astrocytes when stimulated by endogenous agonists and synaptic release of neurotransmitters. These data suggest contribution of NMDA and P2X1/5 receptors to astroglial calcium signalling, which may provide a specific mechanism for fast neuronal-glial signalling at the synaptic level. Workplace Institute of Experimental Medicine Contact Lenka Koželská, lenka.kozelska@iem.cas.cz, Tel.: 241 062 218, 296 442 218 Year of Publishing 2011
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