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CD161 receptor participates in both impairing NK cell cytotoxicity and the response to glycans and vimentin in patients with rheumatoid arthritis
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SYSNO ASEP 0350375 Document Type J - Journal Article R&D Document Type Journal Article Subsidiary J Článek ve WOS Title CD161 receptor participates in both impairing NK cell cytotoxicity and the response to glycans and vimentin in patients with rheumatoid arthritis Author(s) Richter, Jan (MBU-M) RID
Benson, Veronika (MBU-M) RID, ORCID
Grobárová, Valeria (MBU-M)
Svoboda, Jan (MBU-M) RID
Vencovský, J. (CZ)
Svobodová, R. (CZ)
Fišerová, Anna (MBU-M) RIDSource Title Clinical Immunology. - : Elsevier - ISSN 1521-6616
Roč. 136, č. 1 (2010), s. 139-147Number of pages 9 s. Language eng - English Country US - United States Keywords Rheumatoid arthritis ; NK cells ; CD161 Subject RIV EC - Immunology R&D Projects GA310/06/0477 GA ČR - Czech Science Foundation (CSF) GD310/08/H077 GA ČR - Czech Science Foundation (CSF) NR9106 GA MZd - Ministry of Health (MZ) IAA500200620 GA AV ČR - Academy of Sciences of the Czech Republic (AV ČR) CEZ AV0Z50200510 - MBU-M (2005-2011) UT WOS 000278954300015 DOI 10.1016/j.clim.2010.03.005 Annotation High levels of CD161 receptor of NK cells are correlated with impairment of NK cytotoxic activity in RA patients. We propose that MCV plays an important role in RA by increasing expression of CD161, which leads to inhibition of NK cell activity and, consequently, insufficient downregulation of autoreactive T cell, thus accelerating disease progression Workplace Institute of Microbiology Contact Eliška Spurná, eliska.spurna@biomed.cas.cz, Tel.: 241 062 231 Year of Publishing 2011
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