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Real/time monitoring of biomolecular interactions in blood plasma using a surface plasmon resonance biosensor
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SYSNO ASEP 0350305 Document Type J - Journal Article R&D Document Type Journal Article Subsidiary J Článek ve WOS Title Real/time monitoring of biomolecular interactions in blood plasma using a surface plasmon resonance biosensor Author(s) Špringer, Tomáš (URE-Y)
Piliarik, Marek (URE-Y)
Homola, Jiří (URE-Y) RIDNumber of authors 3 Source Title Analytical and Bioanalytical Chemistry. - : Springer - ISSN 1618-2642
Roč. 398, č. 5 (2010), s. 1955-1961Number of pages 7 s. Language eng - English Country DE - Germany Keywords surface plasmon resonance ; molecular interaction analysis ; microfluidics ; optical biosensor Subject RIV BO - Biophysics R&D Projects KAN200670701 GA AV ČR - Academy of Sciences of the Czech Republic (AV ČR) OC09058 GA MŠMT - Ministry of Education, Youth and Sports (MEYS) CEZ AV0Z20670512 - URE-Y (2005-2011) UT WOS 000283244500015 DOI 10.1007/s00216-010-4159-9 Annotation We report a novel biosenor approach which enables real-time monitoring of biomolecular interactions in complex samples. This approach is demonstrated by investigating model interaction between the human chorionic gonadotropin and its antibody in blood plasma using a surface plasmon resonance biosensor and a novel dispersionless microfluidics. The proposed approach also significantly enhance capability of the biosensor to detect biomolecules in complex samples in terms of detection time and sensitivity. Workplace Institute of Radio Engineering and Electronics Contact Petr Vacek, vacek@ufe.cz, Tel.: 266 773 413, 266 773 438, 266 773 488 Year of Publishing 2011
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