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Toward consensus in the analysis of urinary 8-oxo-7,8-dihydro-2'-deoxyguanosine as a noninvasive biomarker of oxidative stress.
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SYSNO ASEP 0350189 Document Type J - Journal Article R&D Document Type Journal Article Subsidiary J Článek ve WOS Title Toward consensus in the analysis of urinary 8-oxo-7,8-dihydro-2'-deoxyguanosine as a noninvasive biomarker of oxidative stress. Author(s) Evans, M. D. (GB)
Olinski, R. (PL)
Loft, M. S. (DK)
Rössner ml., Pavel (UEM-P) RID, ORCID
Šrám, Radim (UEM-P) RIDNumber of authors 43 Source Title FASEB Journal. - : Wiley - ISSN 0892-6638
Roč. 24, č. 4 (2010), s. 1249-1260Number of pages 12 s. Language eng - English Country US - United States Keywords DNA damage ; DNA repair ; immunoassay Subject RIV DN - Health Impact of the Environment Quality CEZ AV0Z50390512 - UEM-P (2005-2011) UT WOS 000276462300031 EID SCOPUS 77951624862 DOI 10.1096/fj.09-147124 Annotation The manuscript compares chromatographic and immunoassay methods used for the detection of urinary 8-oxo-7,8-dihydro-2‘-deoxyguanosine (8-oxodG). Samples containing different concentrations of 8-oxodG were sent to ESCULA members. Data were returned from 17 laboratories, representing 20 detection methods. There was good within-technique agreement for most of the laboratories. ELISA, however, showed more within-technique variation and reported higher 8-oxodG values. Overall, the study reveals greater consensus than previously expected, although some concern remains over ELISA. Workplace Institute of Experimental Medicine Contact Lenka Koželská, lenka.kozelska@iem.cas.cz, Tel.: 241 062 218, 296 442 218 Year of Publishing 2011
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