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Steroid conjugates: Synthesis and preliminary biological testing of pro-juvenoids

SYSNO ASEP	0349942
Document Type	J - Journal Article
R&D Document Type	Journal Article
Subsidiary J	Článek ve WOS
Title	Steroid conjugates: Synthesis and preliminary biological testing of pro-juvenoids
Author(s)	Svobodová, Hana (UEB-Q) Ryšavá, Hana (UEB-Q) Pavlík, Milan (UEB-Q)_{RID, ORCID} Šaman, David (UOCHB-X)_{RID, ORCID} Drašar, Pavel (UOCHB-X) Wimmer, Zdeněk (UEB-Q)_{RID, ORCID}
Source Title	Bioorganic & Medicinal Chemistry. - : Elsevier - ISSN 0968-0896 Roč. 18, č. 23 (2010), s. 8194-8203
Number of pages	10 s.
Language	eng - English
Country	GB - United Kingdom
Keywords	Pyrrhocoris apterus ; Structure–activity relationship ; Juvenoid
Subject RIV	CC - Organic Chemistry
R&D Projects	2B06024 GA MŠMT - Ministry of Education, Youth and Sports (MEYS)
CEZ	AV0Z50380511 - UEB-Q (2005-2011)
	AV0Z40550506 - UOCHB-X (2005-2011)
UT WOS	000284059500008
DOI	10.1016/j.bmc.2010.10.013
Annotation	A series of 10 new pro-juvenoids (juvenogens, insect hormonogenic compounds, pro-drug-like agents) was synthesized using isomeric synthetic juvenoids (insect juvenile hormone analogs) and steroid molecules as patterns modifying parts of the complex hormonogenic molecules. In addition, several new synthons were prepared, which were required by the designed synthetic protocol to achieve the target molecules. These pro-juvenoids were subjected to the topical screening tests and to the drinking assays on the red firebug (Pyrrhocoris apterus), a convenient model laboratory phytophagous insect. Simple and efficient synthetic procedures for the preparation of the target pro-juvenoids and their synthons are presented. Furthermore, the biological activity of the pro-juvenoids in comparison with the activity of their parent juvenoids and that of several commercially available agents is demonstrated.
Workplace	Institute of Experimental Botany
Contact	David Klier, knihovna@ueb.cas.cz, Tel.: 220 390 469
Year of Publishing	2011

Number of the records: 1