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Pyrazolo[4,3-D]pyrimidines, processes for their preparation and methods for therapy

SYSNO ASEP	0349834
Document Type	P - Patent
R&D Document Type	Patent or other outcome protected by special legislation
Title	Pyrazolo[4,3-D]pyrimidines, processes for their preparation and methods for therapy
Author(s)	Moravcová, Daniela (UEB-Q) Havlíček, Libor (UEB-Q)_{RID, ORCID} Kryštof, Vladimír (UEB-Q)_{RID, ORCID} Lenobel, René (UEB-Q)_ORCID Strnad, Miroslav (UEB-Q)_{RID, ORCID}
Year of issue	2010
Possible third party use of the result	A - Pro využití výsledku jiným subjektem je vždy nutné nabytí licence
Royalty requested	A - Poskytovatel licence požaduje licenční poplatek
Patent no. or utility model no. or industrial design no.	US7745450
Date of the patent acceptance	29.06.2010
Name of the patent owner	Ústav experimentální botaniky AV ČR, v. v. i., Univerzita Palackého v Olomouci
Current use	B - Patent je využíván na základě uzavřené licenční smlouvy mezi vlastníkem a uživatelem
Language	eng - English
Country	US - United States
Keywords	pyrazolo[4,3-d]pyrimidines ; anticancer ; anti-inflamatory
Subject RIV	FD - Oncology ; Hematology
R&D Projects	GA301/08/1649 GA ČR - Czech Science Foundation (CSF)
	GA522/09/1576 GA ČR - Czech Science Foundation (CSF)
Annotation	The invention relates to new trisubstituted pyrazolo[4,3-d]pyrimidine derivatives and to their use in suitable utilities, especially diagnostic and therapeutic methods.The compounds are anticancer, anti-inflammatory, antiviral, antineurodegenerative, neurodepressive and immunosuppressive, they have improved selectivity and efficiency index, i.e. that are less toxic yet more efficacious than analogues known.It is an object of this invention to provide 3-, 5-, 7-trisubstituted pyrazolo[4,3-d]pyrimidines, which inhibit the cdks, cell proliferation, and/or induce apoptosis. A further object of the invention is to provide a method for inhibiting cell proliferation and inflammatory diseases to a mammal in need of an effective amount.The solution of this object are 3-, 5-, 7-trisubstituted pyrazolo[4,3-d]pyrimidines of the formula I.
Workplace	Institute of Experimental Botany
Contact	David Klier, knihovna@ueb.cas.cz, Tel.: 220 390 469
Year of Publishing	2011

Number of the records: 1