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AMP-activated Protein Kinase alfa2 Subunit Is Required for the Preservation of Hepatic Insulin Sensitivity by n-3 Polyunsaturated Fatty Acids

SYSNO ASEP	0349619
Document Type	J - Journal Article
R&D Document Type	Journal Article
Subsidiary J	Článek ve WOS
Title	AMP-activated Protein Kinase alfa2 Subunit Is Required for the Preservation of Hepatic Insulin Sensitivity by n-3 Polyunsaturated Fatty Acids
Author(s)	Jeleník, Tomáš (FGU-C) Rossmeisl, Martin (FGU-C)_{RID, ORCID} Kuda, Ondřej (FGU-C)_{RID, ORCID, SAI} Macek Jílková, Zuzana (FGU-C) Medříková, Daša (FGU-C) Kůs, Vladimír (FGU-C) Hensler, Michal (FGU-C) Janovská, Petra (FGU-C)_{RID, ORCID} Mikšík, Ivan (FGU-C)_{RID, ORCID, SAI} Baranowski, M. (PL) Gorski, J. (PL) Hébrard, S. (FR) Jensen, T. E. (DK) Flachs, Pavel (FGU-C)_RID Hawley, S. (GB) Viollet, B. (FR) Kopecký, Jan (FGU-C)_{RID, ORCID}
Source Title	Diabetes. - : American Diabetes Association - ISSN 0012-1797 Roč. 59, č. 11 (2010), s. 2737-2746
Number of pages	10 s.
Language	eng - English
Country	US - United States
Keywords	AMPK ; n-3 LC-PUFA ; insulin resistance
Subject RIV	FB - Endocrinology, Diabetology, Metabolism, Nutrition
R&D Projects	GAP301/10/1420 GA ČR - Czech Science Foundation (CSF)
	1M0520 GA MŠMT - Ministry of Education, Youth and Sports (MEYS)
	OC08007 GA MŠMT - Ministry of Education, Youth and Sports (MEYS)
CEZ	AV0Z50110509 - FGU-C (2005-2011)
UT WOS	000284133400009
DOI	10.2337/db09-1716
Annotation	Mice with a whole-body deletion of the alfa2 catalytic subunit of AMPK and their wild-type littermates were used for testing a hypothesis whether AMP-activated protein kinase (AMPK) has a role in the beneficial effects of n-3 LC-PUFAs. Our results show that n-3 LC-PUFA prevent hepatic insulin resistance in an AMPKalfa2-dependent manner and support the role of adiponectin and hepatic diacylglycerols in the regulation of insulin sensitivity. AMPKα2 is also essential for hypolipidemic and antisteatotic effects of n-3 LC-PUFA under insulin-stimulated conditions
Workplace	Institute of Physiology
Contact	Lucie Trajhanová, lucie.trajhanova@fgu.cas.cz, Tel.: 241 062 400
Year of Publishing	2011

Number of the records: 1