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Polymorphisms of genes coding for ghrelin and its receptor in relation to colorectal cancer risk: a two-step gene-wide case-control study
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SYSNO ASEP 0349610 Document Type J - Journal Article R&D Document Type Journal Article Subsidiary J Článek ve WOS Title Polymorphisms of genes coding for ghrelin and its receptor in relation to colorectal cancer risk: a two-step gene-wide case-control study Author(s) Campa, D. (DE)
Pardini, Barbara (UEM-P)
Naccarati, Alessio (UEM-P)
Vodičková, Ludmila (UEM-P) RID
Novotný, J. (CZ)
Steinke, V. (DE)
Rahner, N. (DE)
Holinski-Feder, E. (DE)
Morak, M. (DE)
Schackert, H. K. (DE)
Görgens, H. (DE)
Kötting, J. (DE)
Betz, B. (DE)
Kloor, M. (DE)
Engel, C. (DE)
Büttner, R. (DE)
Propping, P. (DE)
Försti, A. (SE)
Hemminki, K. (SE)
Barale, R. (IT)
Vodička, Pavel (UEM-P) RID
Canzian, F. (DE)Source Title BMC Gastroenterology
Roč. 10, - (2010), s. 112-117Number of pages 6 s. Language eng - English Country GB - United Kingdom Keywords colorectal cancer ; insulin ; GHSR Subject RIV EB - Genetics ; Molecular Biology R&D Projects GA310/05/2626 GA ČR - Czech Science Foundation (CSF) CEZ AV0Z50390512 - UEM-P (2005-2011) UT WOS 000282779500001 EID SCOPUS 77957116442 DOI 10.1186/1471-230X-10-112 Annotation Ghrelin, an endogenous ligand for the growth hormone secretagogue receptor (GHSR), has two major functions: the stimulation of the growth hormone production and the stimulation of food intake. Accumulating evidence also indicates a role of ghrelin in cancer development. Pairwise tagging was used to select the 11 polymorphisms and the selected polymorphisms were genotyped in cases and controls from the Czech Republic and further verified on the German population. T allele of rs27647 SNP exerted a protective borderline effect (Ptrend = 0.004). Workplace Institute of Experimental Medicine Contact Lenka Koželská, lenka.kozelska@iem.cas.cz, Tel.: 241 062 218, 296 442 218 Year of Publishing 2011
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