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Association between exposure-relevant polymorphisms in CYP1B1, EPHX1, NQO1, GSTM1, GSTP1 and GSTT1 and risk of colorectal cancer in a Czech population
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SYSNO ASEP 0349496 Document Type J - Journal Article R&D Document Type Journal Article Subsidiary J Článek ve WOS Title Association between exposure-relevant polymorphisms in CYP1B1, EPHX1, NQO1, GSTM1, GSTP1 and GSTT1 and risk of colorectal cancer in a Czech population Author(s) Hlavatá, I. (CZ)
Vrána, D. (CZ)
Šmerhovský, Z. (CZ)
Pardini, Barbara (UEM-P)
Naccarati, Alessio (UEM-P)
Vodička, Pavel (UEM-P) RID
Novotný, J. (CZ)
Mohelníková-Duchoňová, B. (CZ)
Souček, P. (CZ)Source Title Oncology Reports - ISSN 1021-335X
Roč. 24, č. 5 (2010), s. 1347-1353Number of pages 7 s. Language eng - English Country GR - Greece Keywords colorectal cancer ; cytochrome P450 ; polymorphism Subject RIV EB - Genetics ; Molecular Biology R&D Projects GA310/07/1430 GA ČR - Czech Science Foundation (CSF) CEZ AV0Z50390512 - UEM-P (2005-2011) UT WOS 000283112200031 EID SCOPUS 78149301724 DOI 10.3892/or_00000992 Annotation The glutathione S-transferase Mu-1 deletion was associated with a moderately elevated colorectal cancer risk (aOR=1.30, CI=1.01-1.68, p=0.044). Combination of glutathione Stransferase Mu-1 and ı-1 deletion was associated with a significantly higher colorectal cancer risk compared to the presence of both full-length genes (aOR=1.58, CI=1.01-2.47, p=0.044). These results provide further evidence that interaction between metabolic gene variants contributes to colorectal carcinogenesis. Workplace Institute of Experimental Medicine Contact Lenka Koželská, lenka.kozelska@iem.cas.cz, Tel.: 241 062 218, 296 442 218 Year of Publishing 2011
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