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Neuroglia in neurodegeneration
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SYSNO ASEP 0349466 Document Type J - Journal Article R&D Document Type Journal Article Subsidiary J Článek ve WOS Title Neuroglia in neurodegeneration Author(s) Heneka, M. T. (DE)
Rodríguez Arellano, Jose Julio (UEM-P)
Verkhratsky, Alexei (UEM-P)Source Title Brain Research Reviews. - : Elsevier - ISSN 0165-0173
Roč. 63, 1-2 (2010), s. 189-211Number of pages 23 s. Language eng - English Country NL - Netherlands Keywords Glia ; Astrocyte ; Microglia Subject RIV FH - Neurology R&D Projects GA309/09/1696 GA ČR - Czech Science Foundation (CSF) GA305/08/1384 GA ČR - Czech Science Foundation (CSF) CEZ AV0Z50390703 - UEM-P (2007-2013) UT WOS 000278034500018 EID SCOPUS 77952428961 DOI 10.1016/j.brainresrev.2009.11.004 Annotation This is a very comprehensive review in which we tackle the fact that as Neuroglial cells are fundamental for control of brain homeostasis and they represent the intrinsic brain defence system; they are in consequence envolved in all forms in neuropathology; which is sustained by the evidence that neurodegenerative processes trigger universal and conserved glial reactions represented by astrogliosis and microglial activation. The complex of recently acquired knowledge allows us to regard the neurodegenerative diseases as primarily gliodegenerative processes, in which glial cells determine the progression and outcome of neuropathological disease Workplace Institute of Experimental Medicine Contact Lenka Koželská, lenka.kozelska@iem.cas.cz, Tel.: 241 062 218, 296 442 218 Year of Publishing 2011
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