Number of the records: 1
Ca(2+) homeostasis, Ca(2+) signalling and somatodendritic vasopressin release in adult rat supraoptic nucleus neurones
- 1.
SYSNO ASEP 0349377 Document Type J - Journal Article R&D Document Type Journal Article Subsidiary J Článek ve WOS Title Ca(2+) homeostasis, Ca(2+) signalling and somatodendritic vasopressin release in adult rat supraoptic nucleus neurones Author(s) Komori, Y. (JP)
Tanaka, M. (JP)
Kuba, M. (JP)
Ishii, M. (JP)
Abe, M. (JP)
Kitamura, N. (JP)
Verkhratsky, Alexei (UEM-P)
Shibuya, I. (JP)
Dayanithi, Govindan (UEM-P) RIDSource Title Cell Calcium. - : Elsevier - ISSN 0143-4160
Roč. 48, č. 6 (2010), s. 324-332Number of pages 9 s. Language eng - English Country DE - Germany Keywords hypothalamus ; cell bodies ; nerve terminals Subject RIV FH - Neurology CEZ AV0Z50390703 - UEM-P (2007-2013) UT WOS 000285815200002 EID SCOPUS 78649712096 DOI 10.1016/j.ceca.2010.10.002 Annotation Multiple mechanisms that maintain Ca2+ homeostasis and provide for Ca2+ signalling operate in the somatas and neurohypophysial nerve terminals of supraoptic nucleus (SON) neurones. We demonstrate that in the fully mature adult rats: (i) all four Ca2+ homeostatic pathways, the Na+/Ca2+ exchanger, the endoplasmic reticulum Ca2+ pump, the plasmalemmal Ca2+ pump and mitochondria, act complementary in clearing Ca2+ loads in SON neurones; (ii) somatodendritic AVP release closely correlates with intracellular [Ca2+]i dynamics; and (iii) Ca2+ homeostatic systems in the somatas of SON neurones differ from those expressed in their terminals. Workplace Institute of Experimental Medicine Contact Lenka Koželská, lenka.kozelska@iem.cas.cz, Tel.: 241 062 218, 296 442 218 Year of Publishing 2011
Number of the records: 1