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Cycloolefin-Copolymer/Polyethylene (COC/PE) Blend Assists with the Creation of New Articular Cartilage
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SYSNO ASEP 0349339 Document Type J - Journal Article R&D Document Type Journal Article Subsidiary J Článek ve WOS Title Cycloolefin-Copolymer/Polyethylene (COC/PE) Blend Assists with the Creation of New Articular Cartilage Author(s) Petrtýl, M. (CZ)
Bastl, Zdeněk (UFCH-W) RID, ORCID
Kruliš, Zdeněk (UMCH-V) RID, ORCID
Hulejová, H. (CZ)
Polanská, M. (CZ)
Lísal, J. (CZ)
Danešová, J. (CZ)
Černý, P. (CZ)Source Title Macromolecular Symposia. - : Wiley - ISSN 1022-1360
294-I, - (2010), s. 120-132Number of pages 13 s. Language eng - English Country DE - Germany Keywords articular cartilage ; biomaterials ; cycloolefin-copolymer blend Subject RIV CF - Physical ; Theoretical Chemistry R&D Projects GA106/06/0761 GA ČR - Czech Science Foundation (CSF) CEZ AV0Z40400503 - UFCH-W (2005-2011) AV0Z40500505 - UMCH-V (2005-2011) UT WOS 000282840400011 DOI 10.1002/masy.201050811 Annotation It is shown that the initial biomechanical stability of the applied COC/PE blend in the treated tissue locality, the initial integrity of biomaterials substituting the subchondral bone by polymer implant, the initial bearing capacity and the vertical position of these biomaterials have a mayor influence on the regeneration of new articular cartilage and subchondral bone. These aspects are essential for a prosperous treatment of osteochondral defects. Results reveal that the initial biomechanical stiffness of materials (substituting the subchondral bone) has a fundamental influence on both the quality and the quantity of new articular cartilage and subchondral bone. Research is also aimed at the application of suitable biologically tolerated polymer material, its surface modifications, verifications of the vertical position of implants in relation to the articular cartilage surface and ensuring the initial biomechanical stability of the polymer implant. Workplace J. Heyrovsky Institute of Physical Chemistry Contact Michaela Knapová, michaela.knapova@jh-inst.cas.cz, Tel.: 266 053 196 Year of Publishing 2011
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