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Acetylcholinesterase and Butyrylcholinesterase Inhibitory Compounds from Eschscholzia californica (Papaveraceae)
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SYSNO ASEP 0349266 Document Type J - Journal Article R&D Document Type Journal Article Subsidiary J Článek ve WOS Title Acetylcholinesterase and Butyrylcholinesterase Inhibitory Compounds from Eschscholzia californica (Papaveraceae) Author(s) Cahlíková, L. (CZ)
Macáková, K. (CZ)
Kuneš, J. (CZ)
Kurfürst, Milan (UCHP-M)
Opletal, L. (CZ)
Cvačka, Josef (UOCHB-X) RID, ORCID
Chlebek, J. (CZ)
Blunden, G. (GB)Source Title Natural Product Communications - ISSN 1934-578X
Roč. 5, č. 7 (2010), s. 1035-1038Number of pages 4 s. Language eng - English Country US - United States Keywords eschscholzia californica ; papaveraceae ; isoquinoline Subject RIV CI - Industrial Chemistry, Chemical Engineering CEZ AV0Z40720504 - UCHP-M (2005-2011) AV0Z40550506 - UOCHB-X (2005-2011) UT WOS 000280117300010 Annotation The roots and aerial parts of Eschscholzia californica Cham. (Papaveraceae) were extracted with ethanol. Repeated column chromatography, preparative TLC, and crystallization led to the isolation of fourteen isoquinoline alkaloids, the structures of which were determined on the basis of spectroscopic techniques and by comparison with literature values. One of the compounds isolated, 1-(3-hydroxy-4-methoxybenzyl)-2-methyl-6,7-methylenedioxy-1,2,3,4-tetrahydroisoquinoline (14), has not previously been isolated from a natural source. All isolated compounds were tested for human blood acetylcholinesterase (HuAChE) and human plasma butyrylcholinesterase (HuBuChE) inhibition activity. None of the compounds isolated significantly inhibited both HuAChE and HuBuChE, but the two benzylisoquinoline alkaloids, reticuline 9 and 14, showed promising inhibitory activity against HuBuChE. Workplace Institute of Chemical Process Fundamentals Contact Eva Jirsová, jirsova@icpf.cas.cz, Tel.: 220 390 227 Year of Publishing 2011
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