Number of the records: 1

Synthesis of alpha-carboxyphosphinopeptides derived from norleucine

SYSNO ASEP	0349249
Document Type	J - Journal Article
R&D Document Type	Journal Article
Subsidiary J	Článek ve WOS
Title	Synthesis of alpha-carboxyphosphinopeptides derived from norleucine
Author(s)	Pícha, Jan (UOCHB-X)_{RID, ORCID} Buděšínský, Miloš (UOCHB-X)_{RID, ORCID} Fiedler, Pavel (UOCHB-X)_RID Šanda, Miloslav (UOCHB-X) Jiráček, Jiří (UOCHB-X)_{RID, ORCID}
Number of authors	5
Source Title	Amino Acids. - : Springer - ISSN 0939-4451 Roč. 39, č. 5 (2010), s. 1265-1280
Number of pages	16 s.
Language	eng - English
Country	AT - Austria
Keywords	phosphinate ; phosphinic ; pseudopeptide ; inhibitor
Subject RIV	CC - Organic Chemistry
R&D Projects	GA203/06/1405 GA ČR - Czech Science Foundation (CSF)
	LC06077 GA MŠMT - Ministry of Education, Youth and Sports (MEYS)
CEZ	AV0Z40550506 - UOCHB-X (2005-2011)
UT WOS	000283502900017
DOI	10.1007/s00726-010-0561-z
Annotation	In the present study, we describe in detail the synthesis of a relatively rare class of phosphorus compounds, a-carboxyphosphinopeptides. We prepared several norleucine-derived a-carboxyphosphinic pseudopeptides of the general formula Nle-[PO(OH)]-Gly. These compounds could find important applications as inhibitors of metalloaminopeptidases.
Workplace	Institute of Organic Chemistry and Biochemistry
Contact	asep@uochb.cas.cz ; Kateřina Šperková, Tel.: 232 002 584 ; Viktorie Chládková, Tel.: 232 002 434
Year of Publishing	2011

Number of the records: 1