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The effect of low dose of vinclozolin on reproductive tract development and sperm parameters in CD1 outbred mice
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SYSNO ASEP 0349100 Document Type C - Proceedings Paper (int. conf.) R&D Document Type Conference Paper Title The effect of low dose of vinclozolin on reproductive tract development and sperm parameters in CD1 outbred mice Author(s) Pěknicová, Jana (BTO-N) RID
Elzeinová, Fatima (BTO-N) RID
Nováková, Vendula (BTO-N)
Buckiová, Daniela (UEM-P)
Kubátová, Alena (BTO-N) RIDSource Title Journal of Andrology - 9th International Congress of Andrology. - Barcelona : The American Society, 2009 / Wang Christina ; Cortada Jordi - ISSN 0196-3635 Pages s. 54-55 Number of pages 2 s. Action 9th International Congress of Andrology Event date 07.03.2009-10.03.2009 VEvent location Barcelona Country ES - Spain Event type WRD Language eng - English Country ES - Spain Keywords vinclozolin ; spermatozoa ; anti-androgen Subject RIV DN - Health Impact of the Environment Quality R&D Projects 1M06011 GA MŠMT - Ministry of Education, Youth and Sports (MEYS) 2B06151 GA MŠMT - Ministry of Education, Youth and Sports (MEYS) CEZ AV0Z50520701 - BTO-N (2007-2013) AV0Z50390703 - UEM-P (2007-2013) UT WOS 000263849500133 Annotation The effect of a low dose of vinclozolin within the development of the reproductive tract during gestation (VIN-GD 15-22) and puberty (VIN-PND 23-44) in CD1 mice was tested. We found a decrease in the anogenital distance, prostate weight and pathology of testes in both experimental groups. Sperm counts decreased to 46% (VIN-GD) and to 81% (VIN-PND), and also the acrosomal state (evaluated by antiacrosomal antibody) decreased in both groups to 89% in comparison to the control group (100%). Sperm head abnormalities increased by approximately 18% and 13%, respectively. In this connection, the expression of some genes was changed (arosome-related gene (Acr), apoptosis related genes (p53, p21)). In conclusion, a low dose of vinclozolin affected the reproductive tract, sperm parameters and expression of selected genes in both experimental groups. Workplace Institute of Biotechnology Contact Monika Kopřivová, Monika.Koprivova@ibt.cas.cz, Tel.: 325 873 700 Year of Publishing 2011
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