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The causes of cancer revisited: "Mitochondrial malignancy" and ROS-induced oncogenic transformation - Why mitochondria are targets for cancer therapy
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SYSNO ASEP 0349092 Document Type J - Journal Article R&D Document Type Journal Article Subsidiary J Článek ve WOS Title The causes of cancer revisited: "Mitochondrial malignancy" and ROS-induced oncogenic transformation - Why mitochondria are targets for cancer therapy Author(s) Ralph, S.J. (AU)
Rodruguez-Enriquez, S. (MX)
Neužil, Jiří (BTO-N) RID
Saavedra, E. (MX)
Moreno-Sanchez, R. (MX)Source Title Molecular Aspects of Medicine. - : Elsevier - ISSN 0098-2997
Roč. 31, č. 2 (2010), s. 145-170Number of pages 25 s. Language eng - English Country NL - Netherlands Keywords Carcinogenesis ; mitocans ; hypoxia Subject RIV FD - Oncology ; Hematology CEZ AV0Z50520701 - BTO-N (2007-2013) UT WOS 000277919600003 DOI 10.1016/j.mam.2010.02.008 Annotation The review is organized into five sections concerning different aspects of "mitochondrial malignancy". The first concerns the functions of mitochondrial ROS and its importance as a pacesetter for cell growth versus senescence and death. The second considers the available evidence that cellular stress in the form of hypoxic and/or hypoglycaemic conditions represent two major triggering events for cancer and how oncoproteins reinforce this process. The third presents evidence that oncoproteins and tumor suppressor proteins physically localize to the mitochondria in cancer cells where they directly regulate malignant mitochondrial programs, including apoptosis. The fourth covers mutational changes in the mitochondrial genome as they relate to malignancy and to the other three areas. The last section concerns the relevance of these findings and their importance for novel approaches to anti-cancer therapy and selective triggering in cancer cells of the mitochondrial apoptotic pathway. Workplace Institute of Biotechnology Contact Monika Kopřivová, Monika.Koprivova@ibt.cas.cz, Tel.: 325 873 700 Year of Publishing 2011
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