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Structures and Organelles in Pathogenic Protists Structures and Organelles in Pathogenic Protists
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SYSNO ASEP 0349085 Document Type M - Monograph Chapter R&D Document Type Monograph Chapter Title The Remarkable Mitochondrion of Trypanosomes and Related Flagellates Author(s) Lukeš, Julius (BC-A) RID, ORCID
Hashimi, Hassan (BC-A) RID, ORCID
Verner, Zdeněk (BC-A)
Číčová, Zdeňka (BC-A)Source Title Structures and Organelles in Pathogenic Protists Structures and Organelles in Pathogenic Protists. - Heidelberg : Springer-Verlag Berlin, 2010 / de Souza Wanderley - ISBN 978-3-642-12862-2 Pages s. 228-252 Number of pages 26 s. Number of copy 2000 Number of pages 323 Language eng - English Country DE - Germany Keywords Mitochondrion ; flagellates Subject RIV EB - Genetics ; Molecular Biology CEZ AV0Z60220518 - PAU-O, BC-A (2005-2011) UT WOS 000282536800010 DOI 10.1007/978-3-642-12863-9_10 Annotation While the single mitochondrion of trypanosomatid flagellates contains many of the hallmarks that are known from mitochondria in other conventional model organisms, it also possesses several unique features, making it a subject of intense research. Here, we summarize current knowledge of the (1) structure, maintenance and replication of the extensive kinetoplastid DNA network, (2) byzantine organellar RNA metabolism, including insertion/deletion RNA editing, (3) translation of mitochondrial-encoded proteins, and, finally, (4) distinctive aspects of energy metabolism of the organelle. While we focus on the mitochondrion of Trypanosoma brucei, particularly in the context of its radical physiological and biochemical changes during the life cycle of the parasite, in order to get a more complete picture of the workings of this fascinating organelle, we also discuss significant findings obtained from other trypanosomatids. Workplace Biology Centre (since 2006) Contact Dana Hypšová, eje@eje.cz, Tel.: 387 775 214 Year of Publishing 2011
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