Number of the records: 1
Allosteric Modulation of Muscarinic Acetylcholine Receptors
- 1.
SYSNO ASEP 0348428 Document Type J - Journal Article R&D Document Type Journal Article Subsidiary J Ostatní články Title Allosteric Modulation of Muscarinic Acetylcholine Receptors Author(s) Jakubík, Jan (FGU-C) RID, ORCID
El-Fakahany, E. E. (US)Source Title Pharmaceuticals. - : MDPI
Roč. 3, č. 9 (2010), s. 2838-2860Number of pages 23 s. Language eng - English Country CH - Switzerland Keywords muscarinic acetylcholine receptors ; allosteric modulation ; Alzheimer´s disease Subject RIV CE - Biochemistry R&D Projects GA305/09/0681 GA ČR - Czech Science Foundation (CSF) CEZ AV0Z50110509 - FGU-C (2005-2011) DOI 10.3390/ph3092838 Annotation This review summarizes over 30 years of reserch on the molecular mechanisms of allosteric interactions of drugs with the receptor and for new allosteric modulators of muscarinic receptors with potential therapeutic use. Identification of positive modulators of acetylcholine binding and function that enhance neurotransmission and the discovery of highly selective allosteric modulators are mile-stones on the way to novel therapeutic agents for the treatment of schizophrenia, Alzheimer´s disease and other involving impaired cognitive function Workplace Institute of Physiology Contact Lucie Trajhanová, lucie.trajhanova@fgu.cas.cz, Tel.: 241 062 400 Year of Publishing 2011
Number of the records: 1