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A trans-acting locus regulates an anti-viral expression network and type 1 diabetes risk
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SYSNO ASEP 0348257 Document Type J - Journal Article R&D Document Type Journal Article Subsidiary J Článek ve WOS Title A trans-acting locus regulates an anti-viral expression network and type 1 diabetes risk Author(s) Heinig, M. (DE)
Petretto, E. (GB)
Wallace, C. (GB)
Bottolo, L. (GB)
Rotival, M. (FR)
Lu, H. (GB)
Li, Y. (GB)
Sarwar, R. (GB)
Langley, S. R. (GB)
Bauerfeind, A. (DE)
Hummel, O. (DE)
Lee, Y. A. (DE)
Paskas, S. (DE)
Rintisch, C. (DE)
Saar, K. (DE)
Cooper, J. (GB)
Buchan, R. (GB)
Gray, C. C. (US)
Cyster, J. G. (US)
Erdmann, J. (DE)
Hengstenberg, C. (DE)
Maouche, S. (FR)
Ouwehand, W. H. (GB)
Rice, C. M. (GB)
Samani, N. J. (GB)
Schunkert, H. (DE)
Goodall, A. H. (GB)
Schulz, H. (DE)
Roider, H. G. (DE)
Vingron, M. (DE)
Blankenberg, S. (DE)
Münzel, T. (DE)
Zeller, T. (DE)
Szymczak, S. (DE)
Ziegler, A. (DE)
Tiret, L. (FR)
Smyth, D. J. (GB)
Pravenec, Michal (FGU-C) RID, ORCID
Aitman, T. J. (GB)
Cambien, F. (FR)
Clayton, D. (GB)
Todd, J. A. (GB)
Hubner, N. (DE)
Cook, S.A. (GB)Source Title Nature. - : Palgrave Macmillan - ISSN 0028-0836
Roč. 467, č. 7314 (2010), s. 460-464Number of pages 5 s. Language eng - English Country GB - United Kingdom Keywords IRF7 driven inflammatory network ; Ebi2 ; type 1 diabetes Subject RIV EB - Genetics ; Molecular Biology R&D Projects 1M0520 GA MŠMT - Ministry of Education, Youth and Sports (MEYS) GAP301/10/0290 GA ČR - Czech Science Foundation (CSF) CEZ AV0Z50110509 - FGU-C (2005-2011) UT WOS 000282090200043 DOI 10.1038/nature09386 Annotation Here we report the use of integrated genome-wide approaches across seven rat tissues to identify gene networks and the loci underlying their regulation. We defined an interferon regulatory factor 7 (IRF73)-driven inflammatory network (IDIN) enriched for viral response genes, which represents a molecular biomarker for macrophages and which was regulated in multiple tissues by a locus on rat chromosome 15q25. We show that Epstein–Barr virus induced gene 2 (Ebi2), which lies at this locus and controls B lymphocyte migration is expressed in macrophages and regulates the IDIN. IDIN genes were more likely to associate with susceptibility to type 1 diabetes (T1D). These data implicate IRF7 network genes and their regulatory locus in the pathogenesis of T1D Workplace Institute of Physiology Contact Lucie Trajhanová, lucie.trajhanova@fgu.cas.cz, Tel.: 241 062 400 Year of Publishing 2011
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