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Long-term adaptation to high doses of morphine causes desensitization of micro-OR- and delta-OR-stimulated G-protein response in forebrain cortex but does not decrease the amount of G-protein alpha subunits
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SYSNO ASEP 0348192 Document Type J - Journal Article R&D Document Type Journal Article Subsidiary J Článek ve WOS Title Long-term adaptation to high doses of morphine causes desensitization of micro-OR- and delta-OR-stimulated G-protein response in forebrain cortex but does not decrease the amount of G-protein alpha subunits Author(s) Bouřová, Lenka (FGU-C)
Vošahlíková, Miroslava (FGU-C) RID, ORCID, SAI
Kagan, D. (CZ)
Dlouhá, Kateřina (FGU-C)
Novotný, J. (CZ)
Svoboda, Petr (FGU-C) RID, ORCIDSource Title Medical Science Monitor - ISSN 1234-1010
Roč. 16, č. 8 (2010), BR260-BR270Number of pages 11 s. Language eng - English Country US - United States Keywords morphine ; G-protein ; opioid receptors Subject RIV CE - Biochemistry R&D Projects IAA500110606 GA AV ČR - Academy of Sciences of the Czech Republic (AV ČR) LC554 GA MŠMT - Ministry of Education, Youth and Sports (MEYS) CEZ AV0Z50110509 - FGU-C (2005-2011) UT WOS 000280762400008 Annotation Our data support the view that the mechanism of the long-term adaptation to high doses of morphine is primarily based on desensitization of opioid receptors-response preferentially oriented to micro- and delta-opioid receptors. Prolonged exposure of rats to high doses of morphine results in decrease of the over-all output of opioid receptors-stimulated G-protein activity in the forebrain cortex but does not decrease the amount of these regulatory proteins Workplace Institute of Physiology Contact Lucie Trajhanová, lucie.trajhanova@fgu.cas.cz, Tel.: 241 062 400 Year of Publishing 2011
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