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Identification of Multiple Substrates of the StkP Ser/Thr Protein Kinase in Streptococcus pneumoniae

SYSNO ASEP	0348138
Document Type	J - Journal Article
R&D Document Type	Journal Article
Subsidiary J	Článek ve WOS
Title	Identification of Multiple Substrates of the StkP Ser/Thr Protein Kinase in Streptococcus pneumoniae
Author(s)	Nováková, Linda (MBU-M)_RID Bezoušková, Silvia (MBU-M) Pompach, Petr (MBU-M)_{RID, ORCID} Přenosilová, Lenka (MBU-M) Weiser, Jaroslav (MBU-M)_RID Branny, Pavel (MBU-M)_{RID, ORCID}
Source Title	Journal of Bacteriology. - : American Society for Microbiology - ISSN 0021-9193 Roč. 192, č. 14 (2010), s. 3629-3638
Number of pages	10 s.
Language	eng - English
Country	US - United States
Keywords	GROUP-B STREPTOCOCCUS ; EUKARYOTIC-TYPE ; SERINE/THREONINE KINASE
Subject RIV	EE - Microbiology, Virology
R&D Projects	GA204/08/0783 GA ČR - Czech Science Foundation (CSF)
	IAA600200801 GA AV ČR - Academy of Sciences of the Czech Republic (AV ČR)
	GP204/07/P082 GA ČR - Czech Science Foundation (CSF)
CEZ	AV0Z50200510 - MBU-M (2005-2011)
UT WOS	000279183300008
DOI	10.1128/JB.01564-09
Annotation	The human pathogen Streptococcus pneumoniae encodes a single copy of a eukaryotic-like Ser/Thr protein kinase gene designated stkP. Previous studies demonstrated the pleiotropic role of the transmembrane protein kinase StkP in pneumococcal physiology. StkP regulates virulence, competence, and stress resistance and plays a role in the regulation of gene expression. In this study we identified three new substrates of StkP: the Mn-dependent inorganic pyrophosphatase PpaC, the hypothetical protein spr0334, and the cell division protein DivIVA. We showed that StkP activation and substrate recognition depend on the presence of a peptidoglycan-binding domain comprising four PASTA domain repeats. We found that StkP is regulated in a growth-dependent manner and likely senses intracellular peptidoglycan subunits present in the cell division septa
Workplace	Institute of Microbiology
Contact	Eliška Spurná, eliska.spurna@biomed.cas.cz, Tel.: 241 062 231
Year of Publishing	2011

Number of the records: 1