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Factors enhancing L-valine production by the growth-limited L-isoleucine auxotrophic strain Corynebacterium glutamicum D-eltailvA D-panB ilvNM13 (pECKAilvBNC)
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SYSNO ASEP 0348125 Document Type J - Journal Article R&D Document Type Journal Article Subsidiary J Článek ve WOS Title Factors enhancing L-valine production by the growth-limited L-isoleucine auxotrophic strain Corynebacterium glutamicum D-eltailvA D-panB ilvNM13 (pECKAilvBNC) Author(s) Denina, I. (LT)
Paegle, L. (LT)
Prouza, Marek (MBU-M)
Holátko, Jiří (MBU-M)
Pátek, Miroslav (MBU-M) RID, ORCID
Nešvera, Jan (MBU-M) RID
Ruklisha, M. (LT)Source Title Journal of Industrial Microbiology & Biotechnology - ISSN 1367-5435
Roč. 37, č. 7 (2010), s. 689-699Number of pages 11 s. Language eng - English Country DE - Germany Keywords Corynebacterium glutamicum ; L-valine synthesis ; Limited growth Subject RIV EE - Microbiology, Virology R&D Projects GC204/07/J012 GA ČR - Czech Science Foundation (CSF) CEZ AV0Z50200510 - MBU-M (2005-2011) UT WOS 000278835500005 DOI 10.1007/s10295-010-0712-y Annotation The influence of stringent response on production of valine in recombinant strain of Corynebacterium glutamicum was tested. Increased production of valine was most probably caused by high activity of acetohydroxy acid synthase, the key enzyme of the biosynthesis of branched-chain amino acids. Positive effect of stringent response was shown in stationary growth phase due to maintaining high activity of acetohydroxy acid synthase and other enzymes of branched-chain amino acid biosynthesis Workplace Institute of Microbiology Contact Eliška Spurná, eliska.spurna@biomed.cas.cz, Tel.: 241 062 231 Year of Publishing 2011
Number of the records: 1