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Long-term pioglitazone treatment augments insulin sensitivity and PKC-epsilon and PKC-theta activation in skeletal muscles in sucrose fed rats

SYSNO ASEP	0347885
Document Type	J - Journal Article
R&D Document Type	Journal Article
Subsidiary J	Článek ve WOS
Title	Long-term pioglitazone treatment augments insulin sensitivity and PKC-epsilon and PKC-theta activation in skeletal muscles in sucrose fed rats
Author(s)	Marková, I. (CZ) Zídek, Václav (FGU-C)_RID Musilová, Alena (FGU-C) Šimáková, Miroslava (FGU-C)_{RID, ORCID} Mlejnek, Petr (FGU-C)_{RID, ORCID} Kazdová, L. (CZ) Pravenec, Michal (FGU-C)_{RID, ORCID}
Source Title	Physiological Research. - : Fyziologický ústav AV ČR, v. v. i. - ISSN 0862-8408 Roč. 59, č. 4 (2010), s. 509-516
Number of pages	8 s.
Language	eng - English
Country	CZ - Czech Republic
Keywords	pioglitazone ; PKC ; insulin resistance
Subject RIV	FB - Endocrinology, Diabetology, Metabolism, Nutrition
R&D Projects	1M0520 GA MŠMT - Ministry of Education, Youth and Sports (MEYS)
	ME08006 GA MŠMT - Ministry of Education, Youth and Sports (MEYS)
	IAA500110604 GA AV ČR - Academy of Sciences of the Czech Republic (AV ČR)
	NR9387 GA MZd - Ministry of Health (MZ)
	NR9359 GA MZd - Ministry of Health (MZ)
	NS9759 GA MZd - Ministry of Health (MZ)
CEZ	AV0Z50110509 - FGU-C (2005-2011)
UT WOS	000282054700004
Annotation	It has been suggested that thiazolidinediones (TZDs) ameliorate insulin resistance in muscle tissue by suppressing muscle lipid storage and the activity of novel protein kinase C (nPKC) isoforms. To test this hypothesis, we analyzed long-term metabolic effects of pioglitazone and the activation of nPKC-epsilon and -theta isoforms in an animal model of the metabolic syndrome, the spontaneously hypertensive rat (a congenic SHR strain with wild type Cd36 gene) fed a diet with 60 % sucrose from the age of 4 to 8 months. Pioglitazone-treated rats exhibited significantly increased membrane/total (cytosolic plus membrane) ratio of both PKC-epsilon and PKC-theta isoforms compared to untreated controls. These results suggest that amelioration of insulin resistance after long-term pioglitazone treatment is associated with increased activation of PKC-epsilon and -theta isoforms in spite of increased lipid concentration in skeletal muscles
Workplace	Institute of Physiology
Contact	Lucie Trajhanová, lucie.trajhanova@fgu.cas.cz, Tel.: 241 062 400
Year of Publishing	2011

Number of the records: 1