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Hemoglobin adducts in 1,3-butadiene exposed Czech workers: Female–male comparisons
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SYSNO ASEP 0347670 Document Type J - Journal Article R&D Document Type Journal Article Subsidiary J Článek ve WOS Title Hemoglobin adducts in 1,3-butadiene exposed Czech workers: Female–male comparisons Author(s) Vacek, P. M. (US)
Albertini, R. J. (US)
Šrám, Radim (UEM-P) RID
Upton, P. (US)
Swenberg, J. A. (US)Source Title Chemico-Biological Interactions. - : Elsevier - ISSN 0009-2797
Roč. 188, č. 3 (2010), s. 668-676Number of pages 9 s. Language eng - English Country IE - Ireland Keywords 3-Butadiene ; metabolism ; THB-Val hemoglobin adducts Subject RIV DN - Health Impact of the Environment Quality CEZ AV0Z50390512 - UEM-P (2005-2011) UT WOS 000285169100035 EID SCOPUS 78149471572 DOI 10.1016/j.cbi.2010.06.017 Annotation The results of this study confirm the findings of the previous molecular epidemiological study of female and male 1,3-butadiene (BD) exposed Czech workers, showing that females appeared to absorb or metabolize less BD per unit exposure conc. that did males (based on metabolite conc. in urine). In this study, another biomarker to measure a second metabolite of BD was used. The authors measured production and accumulation of the 1,2-dihydroxy-3,4-epoxybutane (EBD) metabolite as reflected in THB-Val hemoglobin adduct concentrations. In both the control and exposed groups mean THB-Val concentrations were significantly higher for males than females. It was also found that the size of difference increased with exposure. Workplace Institute of Experimental Medicine Contact Lenka Koželská, lenka.kozelska@iem.cas.cz, Tel.: 241 062 218, 296 442 218 Year of Publishing 2011
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