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An acellular assay to assess the genotoxicity of complex mixtures of organic pollutants bound on size segregated aerosol. Part I: DNA adducts
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SYSNO ASEP 0347664 Document Type J - Journal Article R&D Document Type Journal Article Subsidiary J Článek ve WOS Title An acellular assay to assess the genotoxicity of complex mixtures of organic pollutants bound on size segregated aerosol. Part I: DNA adducts Author(s) Topinka, Jan (UEM-P) RID, ORCID
Hovorka, J. (CZ)
Milcová, Alena (UEM-P)
Schmuczerová, Jana (UEM-P) RID
Kroužek, J. (CZ)
Rössner ml., Pavel (UEM-P) RID, ORCID
Šrám, Radim (UEM-P) RIDSource Title Toxicology Letters. - : Elsevier - ISSN 0378-4274
Roč. 198, č. 1 (2010), s. 304-311Number of pages 8 s. Language eng - English Country IE - Ireland Keywords Air pollution ; Complex mixtures ; DNA adducts Subject RIV DN - Health Impact of the Environment Quality R&D Projects 2B08005 GA MŠMT - Ministry of Education, Youth and Sports (MEYS) CEZ AV0Z50390512 - UEM-P (2005-2011) UT WOS 000282855300002 EID SCOPUS 77956516015 DOI 10.1016/j.toxlet.2010.06.016 Annotation The genotoxicity of the organic extracts (EOMs) from three size fractions of aerosols (ranging from 0.17 to 10µm and collected in 4 localities differing in the extent of pollution) was compared using the analysis of total DNA adducts induced in an acellular assay with/without metabolic activation. It was found that most of the observed genotoxicity was connected with a fine particulate matter fraction (<1µm). These fine fractions bound the highest amount of c-PAHs in all aerosol sites, which might be related to their higher specific surface. As for aerosol mass, both fine and condensational fractions are effective carriers of c-PAHs. Similarly, the DNA adduct levels per m3 of air were highest for the fine fraction and a strong correlation was found between the c-PAHs and DNA adduct levels induced by EOMs in all the localities and for various size fractions. Workplace Institute of Experimental Medicine Contact Lenka Koželská, lenka.kozelska@iem.cas.cz, Tel.: 241 062 218, 296 442 218 Year of Publishing 2011
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