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Associations between Polycyclic Aromatic Hydrocarbon-Related Exposures and p53 Mutations in Breast Tumors
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SYSNO ASEP 0347653 Document Type J - Journal Article R&D Document Type Journal Article Subsidiary J Článek ve WOS Title Associations between Polycyclic Aromatic Hydrocarbon-Related Exposures and p53 Mutations in Breast Tumors Author(s) Mordukhovich, I. (US)
Rössner ml., Pavel (UEM-P) RID, ORCID
Terry, M. B. (US)
Santella, R. (US)
Zhang, Y.J. (US)
Hibshoosh, H. (US)
Memeo, L. (IT)
Mansukhani, M. (US)
Long, CH.M. (US)
Garbowski, G. (US)
Agrawal, M. (US)
Gaudet, M. M. (US)
Steck, S. E. (US)
Sagiv, S. K. (US)
Eng, S. M. (US)
Teitelbaum, S. L. (US)
Neugut, A. I. (US)
Conway-Dorsey, K. (US)
Gammon, M. D. (US)Source Title Environmental Health Perspectives. - : U.S. Department of Health and Human Services - ISSN 0091-6765
Roč. 118, č. 4 (2010), s. 511-518Number of pages 8 s. Language eng - English Country US - United States Keywords breast cancer ; p53 mutation ; p53 overexpression Subject RIV DN - Health Impact of the Environment Quality CEZ AV0Z50390512 - UEM-P (2005-2011) UT WOS 000276454800024 EID SCOPUS 77951675375 DOI 10.1289/ehp.0901233 Annotation The study tested the hypothesis that associations of PAH-related exposures with breast cancer differ according to tumor p53 mutation status, effect, type, and number. This possibility was examined in a population-based case-control study where p53 mutations in 859 tumors were detected. Participants with p53 mutations were less likely to be exposed to polycyclic aromatic hydrocarbons (PAHs) than participants without mutations. In conclusion, the study suggests that PAHs may be associated with specific breast tumor p53 mutation subgroup rather than with overall p53 mutations and may be related to breast cancer through mechanisms other than p53 mutation. Workplace Institute of Experimental Medicine Contact Lenka Koželská, lenka.kozelska@iem.cas.cz, Tel.: 241 062 218, 296 442 218 Year of Publishing 2011
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