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Reduced UVB-induced corneal damage caused by reactive oxygen and nitrogen species and decreased changes in corneal optics after trehalose treatment
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SYSNO ASEP 0347608 Document Type J - Journal Article R&D Document Type Journal Article Subsidiary J Článek ve WOS Title Reduced UVB-induced corneal damage caused by reactive oxygen and nitrogen species and decreased changes in corneal optics after trehalose treatment Author(s) Čejková, Jitka (UEM-P) RID
Čejka, Čestmír (UEM-P) RID
Ardan, Taras (UEM-P)
Širc, Jakub (UMCH-V) RID, ORCID
Michálek, Jiří (UMCH-V) RID, ORCID
Luyckx, J. (FR)Source Title Histology and Histopathology. - : Universidad de Murcia - ISSN 0213-3911
Roč. 25, č. 11 (2010), s. 1403-1416Number of pages 14 s. Language eng - English Country ES - Spain Keywords UVB rays ; Rabbit cornea ; Trehalose treatment Subject RIV FF - HEENT, Dentistry CEZ AV0Z50390512 - UEM-P (2005-2011) AV0Z40500505 - UMCH-V (2005-2011) UT WOS 000282136800005 Annotation Trehalose, a nonreducing disaccharide of glucose, is synthetized as a stress responsive factor when cells are exposed to various stress conditions. In UVB-irradiated cornea the effect of trehalose was compared with eyes treated with buffered saline during irradiation. Results show that trehalose significantly reduced oxidative damage of the cornea induced by UVB rays. Trehalose reduced changes of corneal optics, suppressed apoptosis of corneal cells and decreased the formation of peroxynitrite, the reaction product between superoxide and nitric oxide. Workplace Institute of Experimental Medicine Contact Lenka Koželská, lenka.kozelska@iem.cas.cz, Tel.: 241 062 218, 296 442 218 Year of Publishing 2011
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