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Genome-wide association study for colorectal cancer identifies risk polymorphisms in German familial cases and implicates MAPK signalling pathways in disease susceptibility
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SYSNO ASEP 0347490 Document Type J - Journal Article R&D Document Type Journal Article Subsidiary J Článek ve WOS Title Genome-wide association study for colorectal cancer identifies risk polymorphisms in German familial cases and implicates MAPK signalling pathways in disease susceptibility Author(s) Lascors, J. (DE)
Försti, A. (SE)
Chen, B. (DE)
Buch, S. (DE)
Steinke, V. (DE)
Rahner, N. (DE)
Holinski-Feder, E. (DE)
Morak, M. (DE)
Schackert, H. K. (DE)
Görgens, H. (DE)
Schulmann, K. (DE)
Goecke, T. (DE)
Kloor, M. (DE)
Engel, C. (DE)
Büttner, R. (DE)
Kunkel, N. (DE)
Weires, M. (DE)
Hoffmeister, M. (DE)
Pardini, Barbara (UEM-P)
Naccarati, Alessio (UEM-P)
Vodičková, Ludmila (UEM-P) RID
Novotný, J. (CZ)
Schreiber, S. (DE)
Krawczak, M. (DE)
Bröring, C. D. (DE)
Völzke, H. (DE)
Schafmayer, C. (DE)
Vodička, Pavel (UEM-P) RID
Chang-Claude, J. (DE)
Brenner, H. (DE)
Burwinkel, B. (DE)
Propping, P. (DE)
Hampe, J. (DE)
Hemminki, K. (SE)Source Title Carcinogenesis. - : Oxford University Press - ISSN 0143-3334
Roč. 31, č. 9 (2010), s. 1612-1619Number of pages 8 s. Language eng - English Country GB - United Kingdom Keywords colorectal cancer ; gene ontology ; confidence interval Subject RIV EB - Genetics ; Molecular Biology R&D Projects GA310/07/1430 GA ČR - Czech Science Foundation (CSF) CEZ AV0Z50390512 - UEM-P (2005-2011) UT WOS 000281530400015 EID SCOPUS 77956281205 DOI 10.1093/carcin/bgq146 Annotation In this GWAs study, 10 664 genotyped single-nucleotide polymorphisms (SNPs) passed the quality control filtering in 371 German familial CRC patients and 1263 controls, and replication studies were conducted in four additional case-control sets (4915 cases and 5607 controls). We have observed that the risk of CRC increased significantly with an increasing number of risk alleles in seven genes involved in MAPK signalling events. Workplace Institute of Experimental Medicine Contact Lenka Koželská, lenka.kozelska@iem.cas.cz, Tel.: 241 062 218, 296 442 218 Year of Publishing 2011
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