New bradykinin B-2 receptor antagonists - influence of C-terminal segment modifications on their pharmacological properties
1.
SYSNO ASEP
0347364
Document Type
J - Journal Article
R&D Document Type
Journal Article
Subsidiary J
Článek ve WOS
Title
New bradykinin B-2 receptor antagonists - influence of C-terminal segment modifications on their pharmacological properties
Author(s)
Sleszynska, M. (PL) Kwiatkowska, A. (PL) Sobolewski, D. (PL) Wierzba, T. H. (PL) Katarzynska, J. (PL) Zabrocki, J. (PL) Borovičková, Lenka (UOCHB-X) Slaninová, Jiřina (UOCHB-X) Prahl, A. (PL)
Number of authors
9
Source Title
Acta Biochimica Polonica
- ISSN 0001-527X
Roč. 56, č. 4 (2009), s. 641-648
Number of pages
8 s.
Language
eng - English
Country
PL - Poland
Keywords
bradykinin
Subject RIV
CC - Organic Chemistry
CEZ
AV0Z40550506 - UOCHB-X (2005-2011)
UT WOS
000276702200008
Annotation
Analogues of the bradykinin antagonist [D-Arg(0),Hyp(3),Thi(5,8),D-Phe(7)]BK having in position 7 or 8 L-pipecolic acid or L-beta(2)-isoproline or L-beta(3)-homoproline and free or acylated N-terminal amino group were synthesized and biologically evaluated (isolated rat uterus and rat blood pressure tests). The results thus support the hypothesis about the existence of different types of BK receptors in the rat uterus and blood vessels.
