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In position 7 l- and d-Tic-substituted oxytocin and deamino oxytocin: NMR study and conformational insights
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SYSNO ASEP 0347360 Document Type J - Journal Article R&D Document Type Journal Article Subsidiary J Článek ve WOS Title In position 7 l- and d-Tic-substituted oxytocin and deamino oxytocin: NMR study and conformational insights Author(s) Spyranti, Z. (GR)
Fragiadaki, M. (GR)
Magafa, V. (GR)
Borovičková, Lenka (UOCHB-X)
Spyroulias, G. A. (GR)
Cordopatis, P. (GR)
Slaninová, Jiřina (UOCHB-X)Number of authors 7 Source Title Amino Acids. - : Springer - ISSN 0939-4451
Roč. 39, č. 2 (2010), s. 539-548Number of pages 10 s. Language eng - English Country AT - Austria Keywords oxytocin analogues ; deaminooxytocin ; NMR Subject RIV CC - Organic Chemistry CEZ AV0Z40550506 - UOCHB-X (2005-2011) UT WOS 000279190400024 DOI 10.1007/s00726-009-0470-1 Annotation NMR study (NOESY, TOCSY, H-1-C-13 HSQC spectra) of analogues of oxytocin and deaminoocytocin having in position 7 L- or D-Tic is presented. The existence of both cis and trans configurations of the Cys(6)-D-Tic(7) bond is supported by observation of two sets of cross-peaks for H-1 and C-13 nuclei for most of the residues of the peptide not only in NOESY and TOCSY but also in H-1-C-13 HSQC spectra. The MS and HPLC indicate the presence of a single molecule/peptide, and NMR data thus suggest that this second set of peaks is due to the cis conformation. Workplace Institute of Organic Chemistry and Biochemistry Contact asep@uochb.cas.cz ; Kateřina Šperková, Tel.: 232 002 584 ; Viktorie Chládková, Tel.: 232 002 434 Year of Publishing 2011
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