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Genotoxic polycyclic aromatic hydrocarbons fail to induce the p53-dependent DNA damage response, apoptosis or cell-cycle arrest in human prostate carcinoma LNCaP cells
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SYSNO ASEP 0347299 Document Type J - Journal Article R&D Document Type Journal Article Subsidiary J Článek ve WOS Title Genotoxic polycyclic aromatic hydrocarbons fail to induce the p53-dependent DNA damage response, apoptosis or cell-cycle arrest in human prostate carcinoma LNCaP cells Author(s) Hrubá, E. (CZ)
Trilecová, L. (CZ)
Marvanová, S. (CZ)
Krčmář, P. (CZ)
Vykopalová, L. (CZ)
Milcová, Alena (UEM-P)
Líbalová, Helena (UEM-P) RID
Topinka, Jan (UEM-P) RID, ORCID
Staršíchová, Andrea (BFU-R)
Souček, Karel (BFU-R) RID, ORCID
Vondráček, Jan (BFU-R) RID, ORCID
Machala, M. (CZ)Number of authors 12 Source Title Toxicology Letters. - : Elsevier - ISSN 0378-4274
Roč. 198, č. 3 (2010), s. 227-235Number of pages 9 s. Language eng - English Country IE - Ireland Keywords prostate epithelial cells ; DNA adducts ; carcinogenesis Subject RIV BO - Biophysics CEZ AV0Z50040507 - BFU-R (2005-2011) AV0Z50040702 - BFU-R (2007-2013) AV0Z50390512 - UEM-P (2005-2011) AV0Z50390703 - UEM-P (2007-2013) UT WOS 000281002700011 DOI 10.1016/j.toxlet.2010.06.004 Annotation In the present study, we documented, for the first time, that although genotoxic PAHs produce significant levels of DNA adducts in the model of human prostate carcinoma cells, they do not activate the mechanisms leading to elimination of cells with significant DNA damage, presumably due to their failure to activate the p53-dependent DNA damage response. Workplace Institute of Biophysics Contact Jana Poláková, polakova@ibp.cz, Tel.: 541 517 244 Year of Publishing 2011
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