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Tumor necrosis factor α sensitizes spinal cord TRPV1 receptors to the endogenous agonist N-oleoyldopamine

SYSNO ASEP	0347210
Document Type	J - Journal Article
R&D Document Type	Journal Article
Subsidiary J	Článek ve WOS
Title	Tumor necrosis factor α sensitizes spinal cord TRPV1 receptors to the endogenous agonist N-oleoyldopamine
Author(s)	Špicarová, Diana (FGU-C)_{RID, ORCID} Paleček, Jiří (FGU-C)_{RID, ORCID}
Source Title	Journal of Neuroinflammation. - : Filtch Solutions Roč. 7, - (2010), s. 49-7
Number of pages	7 s.
Language	eng - English
Country	GB - United Kingdom
Keywords	TNF ; TRPV1 ; pain
Subject RIV	FH - Neurology
R&D Projects	LC554 GA MŠMT - Ministry of Education, Youth and Sports (MEYS)
	GA305/09/1228 GA ČR - Czech Science Foundation (CSF)
CEZ	AV0Z50110509 - FGU-C (2005-2011)
UT WOS	000282385800001
DOI	10.1186/1742-2094-7-49
Annotation	In our experiments the possible influence of TNFa on presynaptic spinal cord TRPV1 receptor function was investigated. Our results indicate that TNFa may have a significant impact on nociceptive signaling at the spinal cord level that could be mediated by increased responsiveness of presynaptic TRPV1 receptors to endogenous agonists. This could be of major importance, especially during pathological conditions, when increased levels of TNFa and TNFR are present in the spinal cord
Workplace	Institute of Physiology
Contact	Lucie Trajhanová, lucie.trajhanova@fgu.cas.cz, Tel.: 241 062 400
Year of Publishing	2011

Number of the records: 1