Number of the records: 1

Genetic structure and contrasting selection pattern at two major histocompatibility complex genes in wild house mouse populations

SYSNO ASEP	0347205
Document Type	J - Journal Article
R&D Document Type	Journal Article
Subsidiary J	Článek ve WOS
Title	Genetic structure and contrasting selection pattern at two major histocompatibility complex genes in wild house mouse populations
Author(s)	Čížková, Dagmar (UBO-W)_{RID, SAI, ORCID} Goüy de Bellocq, J. (BE) Baird, S. J. E. (PT) Piálek, Jaroslav (UBO-W)_{RID, ORCID, SAI} Bryja, Josef (UBO-W)_{RID, SAI, ORCID}
Number of authors	5
Source Title	Heredity - ISSN 0018-067X Roč. 106, č. 5 (2011), s. 727-740
Number of pages	14 s.
Language	eng - English
Country	GB - United Kingdom
Keywords	MHC ; house mouse ; selection ; population structure ; trans-species polymorphism
Subject RIV	EB - Genetics ; Molecular Biology
R&D Projects	IAA600930608 GA AV ČR - Academy of Sciences of the Czech Republic (AV ČR)
	GA206/08/0640 GA ČR - Czech Science Foundation (CSF)
CEZ	AV0Z60930519 - UBO-W (2005-2011)
UT WOS	000289713700005
EID SCOPUS	79955099391
DOI	10.1038/hdy.2010.112
Annotation	The mammalian major histocompatibility complex (MHC) is a tightly linked cluster of immune genes, and is often thought of as inherited as a unit. This has led to the hope that studying a single MHC gene will reveal patterns of evolution representative of the MHC as a whole. In this study we analyse a 1000-km transect of MHC variation in house mice to compare signals of selection and patterns of diversification at two closely linked MHC class II genes, H-2Aa and H-2Eb. We show that although they are 0.01cM apart, disparate evolutionary patterns were detected. H-2Aa shows higher allelic polymorphism, faster allelic turnover due to higher mutation rates, stronger positive selection at antigen-binding sites and higher population structuring than H-2Eb. H-2Eb alleles are maintained in the gene pool for longer, including over separation of the subspecies, some H-2Eb alleles are positively and others negatively selected and some of the alleles are not expressed.
Workplace	Institute of Vertebrate Biology
Contact	Hana Slabáková, slabakova@ivb.cz, Tel.: 543 422 524
Year of Publishing	2012

Number of the records: 1