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A metal-free DNA nuclease based on a cyclic peptide scaffold
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SYSNO ASEP 0347181 Document Type J - Journal Article R&D Document Type Journal Article Subsidiary J Článek ve WOS Title A metal-free DNA nuclease based on a cyclic peptide scaffold Author(s) Alkhader, S. (IL)
Ezra, A. (IL)
Kašpárková, Jana (BFU-R) RID, ORCID
Brabec, Viktor (BFU-R) RID, ORCID
Yavin, E. (IL)Number of authors 5 Source Title Bioconjugate Chemistry. - : American Chemical Society - ISSN 1043-1802
Roč. 21, č. 8 (2010), s. 1425-1431Number of pages 7 s. Language eng - English Country US - United States Keywords DNA ; cleavage ; chemical nuclease Subject RIV BO - Biophysics R&D Projects IAA400040803 GA AV ČR - Academy of Sciences of the Czech Republic (AV ČR) LC06030 GA MŠMT - Ministry of Education, Youth and Sports (MEYS) ME08017 GA MŠMT - Ministry of Education, Youth and Sports (MEYS) OC08003 GA MŠMT - Ministry of Education, Youth and Sports (MEYS) KAN200200651 GA AV ČR - Academy of Sciences of the Czech Republic (AV ČR) CEZ AV0Z50040507 - BFU-R (2005-2011) AV0Z50040702 - BFU-R (2007-2013) UT WOS 000280918900006 DOI 10.1021/bc900543b Annotation This work describes DNA nuclease activity of conjugates composed of the cyclic peptide cyc-D-Lys-Gly-Arg-Ser-Arg conjugated to anthraquinone highlighting the various chemical features that are required for efficient DNA degradation by such metal-free DNA cutters. Workplace Institute of Biophysics Contact Jana Poláková, polakova@ibp.cz, Tel.: 541 517 244 Year of Publishing 2011
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