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Porphyrin-cyclodextrin conjugates as a nanosystem for versatile drug delivery and multimodal cancer therapy
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SYSNO ASEP 0347154 Document Type J - Journal Article R&D Document Type Journal Article Subsidiary J Článek ve WOS Title Porphyrin-cyclodextrin conjugates as a nanosystem for versatile drug delivery and multimodal cancer therapy Author(s) Králová, Jarmila (UMG-J) RID
Kejík, Z. (CZ)
Bříza, T. (CZ)
Poučková, P. (CZ)
Kral, A. (CZ)
Martásek, P. (CZ)
Král, V. (CZ)Source Title Journal of Medicinal Chemistry. - : American Chemical Society - ISSN 0022-2623
Roč. 53, č. 1 (2010), s. 128-138Number of pages 11 s. Language eng - English Country US - United States Keywords photodynamic therapy ; cancer therapy ; porphyrin conjugate Subject RIV EB - Genetics ; Molecular Biology CEZ AV0Z50520514 - UMG-J (2005-2011) UT WOS 000273268300010 DOI 10.1021/jm9007278 Annotation The porphyrin-cyclodextrin conjugates were prepared and tested for selective and effective multi-functional drug delivery and therapy. The porphyrin receptor system combines efficient binding of the selected drug to the cyclodextrin cavity and photosensitizing properties of the porphyrin moiety with high accumulation of the whole complex in cancer tissue. The combined effect of chemotherapy and photodynamic therapy is demonstrated by in vitro and in vivo studies. Workplace Institute of Molecular Genetics Contact Nikol Škňouřilová, nikol.sknourilova@img.cas.cz, Tel.: 241 063 217 Year of Publishing 2011
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