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Bacterial intoxication evokes cellular senescence with persistent DNA damage and cytokine signalling
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SYSNO ASEP 0347149 Document Type J - Journal Article R&D Document Type Journal Article Subsidiary J Článek ve WOS Title Bacterial intoxication evokes cellular senescence with persistent DNA damage and cytokine signalling Author(s) Blažková, Hana (UMG-J)
Krejčíková, Kateřina (UMG-J)
Moudrý, Pavel (UMG-J)
Frisan, T. (SE)
Hodný, Zdeněk (UMG-J) RID
Bártek, Jiří (UMG-J) RIDSource Title Journal of Cellular and Molecular Medicine. - : Wiley - ISSN 1582-1838
Roč. 14, 1-2 (2009), s. 357-367Number of pages 11 s. Language eng - English Country GB - United Kingdom Keywords cellular senescence ; DNA damage response ; bacterial toxins Subject RIV EB - Genetics ; Molecular Biology R&D Projects IAA500390501 GA AV ČR - Academy of Sciences of the Czech Republic (AV ČR) GA204/08/1418 GA ČR - Czech Science Foundation (CSF) GA301/08/0353 GA ČR - Czech Science Foundation (CSF) CEZ AV0Z50520514 - UMG-J (2005-2011) UT WOS 000275639700031 DOI 10.1111/j.1582-4934.2009.00862.x Annotation Cytolethal distending toxins (CDT) are proteins produced and secreted by facultative pathogenic strains of gram-negative bacteria with potentially genotoxic effects. We found both normal and cancer human cells exposed to CDT, surviving the acute phase of intoxication by Haemophilus ducreyi CDT, possess the main hallmarks of cellular senescence including persistently activated DNA damage signalling, expansion of promyelocytic leukaemia nuclear compartment and induced expression of several cytokines (e.g. IL-6, IL-8 and IL-24). We conclude that analogous to oncogenic, oxidative and replicative stresses, bacterial toxins represent another pathophysiological stimulus that induces premature senescence. Thus, the activation of cellular senescence as the anticancer barrier, together with evidence of chromosomal defects reported here, support the emerging genotoxic and potentially oncogenic effects of this group of bacterial toxins, and warrant further research of their role in human disease. Workplace Institute of Molecular Genetics Contact Nikol Škňouřilová, nikol.sknourilova@img.cas.cz, Tel.: 241 063 217 Year of Publishing 2011
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