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Circulating nucleic acids as a new diagnostic tool
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SYSNO ASEP 0347088 Document Type J - Journal Article R&D Document Type Journal Article Subsidiary J Článek ve WOS Title Circulating nucleic acids as a new diagnostic tool Author(s) Urbanová, Markéta (UMG-J)
Plzák, J. (CZ)
Strnad, Hynek (UMG-J) RID
Betka, J. (CZ)Source Title Cellular & Molecular Biology Letters - ISSN 1425-8153
Roč. 15, č. 2 (2010), s. 242-259Number of pages 18 s. Language eng - English Country PL - Poland Keywords circulating nucleic acids ; diagnostics ; cancer Subject RIV EB - Genetics ; Molecular Biology R&D Projects 2B06106 GA MŠMT - Ministry of Education, Youth and Sports (MEYS) CEZ AV0Z50520514 - UMG-J (2005-2011) UT WOS 000275966600005 DOI 10.2478/s11658-010-0004-6 Annotation The discovery of circulating nucleic acids in the 1940s opened up new possibilities for the non-invasive detection, monitoring and screening of various human disorders. Several tumour markers that enable early cancer detection or tumour behaviour prediction have been detected in the plasma of cancer patients. Maternal plasma analysis can be used to detect certain fetal abnormalities, with the quantification of cell-free nucleic acids used to screen for several pregnancy-associated disorders. Some other applications are in transplant monitoring and graft rejection assessment, and in certain medical emergencies such as trauma and burn severity stratification. Many studies have yielded promising results in this field, but the techniques have yet to be applied in routine clinical practice. Large-scale studies using similar technologies and a broad spectrum of patients are still needed to verify the results of the various studies. Workplace Institute of Molecular Genetics Contact Nikol Škňouřilová, nikol.sknourilova@img.cas.cz, Tel.: 241 063 217 Year of Publishing 2011
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