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pH sensitive polymer nanoparticles: effect of hydrophobicity on self-assembly

SYSNO ASEP	0347038
Document Type	J - Journal Article
R&D Document Type	Journal Article
Subsidiary J	Článek ve WOS
Title	pH sensitive polymer nanoparticles: effect of hydrophobicity on self-assembly
Author(s)	Filippov, Sergey K. (UMCH-V)_{RID, ORCID, SAI} Starovoytova, Larisa (UMCH-V)_RID Koňák, Čestmír (UMCH-V)_RID Hrubý, Martin (UMCH-V)_{RID, ORCID} Macková, Hana (UMCH-V)_RID Karlsson, G. (SE) Štěpánek, Petr (UMCH-V)_{RID, ORCID}
Source Title	Langmuir. - : American Chemical Society - ISSN 0743-7463 Roč. 26, č. 18 (2010), s. 14450-14457
Number of pages	8 s.
Language	eng - English
Country	US - United States
Keywords	complex ; hydrophobicity ; surfactant
Subject RIV	CD - Macromolecular Chemistry
R&D Projects	GAP208/10/1600 GA ČR - Czech Science Foundation (CSF)
	IAA100500501 GA AV ČR - Academy of Sciences of the Czech Republic (AV ČR)
	GPP207/10/P054 GA ČR - Czech Science Foundation (CSF)
	GESON/06/E005 GA ČR - Czech Science Foundation (CSF)
CEZ	AV0Z40500505 - UMCH-V (2005-2011)
UT WOS	000281690600013
DOI	10.1021/la1018778
Annotation	For the first time, we have described the detailed mechanism of the formation of pH-sensitive nanoparticles with varying pH using dynamic information from NMR, charge properties from zeta-potential, aggregation behavior from light scattering, and particle imaging using cryo-TEM. We have shown that, at basic conditions, a polymer-surfactant complex with pearl-necklace structure exists. At lower pH, globulized complexes occur due to coil-to-globule transition of a polyanion. With a further decrease of pH, the globulized complexes assemble into larger nanoparticles that are stabilized by streric repulsion of hydrophilic PEO chains of the surfactant.
Workplace	Institute of Macromolecular Chemistry
Contact	Eva Čechová, cechova@imc.cas.cz ; Tel.: 296 809 358
Year of Publishing	2011

Number of the records: 1