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Distribution of polyethylene wear particles and bone fragments in periprosthetic tissue around total hip joint replacements
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SYSNO ASEP 0347024 Document Type J - Journal Article R&D Document Type Journal Article Subsidiary J Článek ve WOS Title Distribution of polyethylene wear particles and bone fragments in periprosthetic tissue around total hip joint replacements Author(s) Zolotarevova, E. (CZ)
Entlicher, G. (CZ)
Pavlova, Ewa (UMCH-V) RID
Šlouf, Miroslav (UMCH-V) RID, ORCID
Pokorný, D. (CZ)
Veselý, F. (CZ)
Gallo, J. (CZ)
Sosna, A. (CZ)Source Title Acta Biomaterialia. - : Elsevier - ISSN 1742-7061
Roč. 6, č. 9 (2010), s. 3595-3600Number of pages 6 s. Language eng - English Country GB - United Kingdom Keywords joint replacement ; polyethylene ; wear particles distribution Subject RIV CD - Macromolecular Chemistry R&D Projects 2B06096 GA MŠMT - Ministry of Education, Youth and Sports (MEYS) CEZ AV0Z40500505 - UMCH-V (2005-2011) UT WOS 000281318400026 DOI 10.1016/j.actbio.2010.04.010 Annotation Ultra-high molecular weight polyethylene (UHMWPE) wear particles play a significant role in failures of total joint replacements (TJRs). In this work, we investigated the distribution of these wear particles in periprosthetic tissues obtained from nine revisions of hip TJR. All periprosthetic tissues were combined and mechanically separated into granuloma tissue (containing hard granules visible to the naked eye) and surrounding tissue (without visible granules). Of the total amount of polyethylene particles in the whole granuloma tissue, 72% of particles in the size range 0.1–10 um and 68% of those larger than 10 um were found in granules. Therefore, the formation of granules significantly lowers the effective amount of wear particles available for interaction with reactive cells and seems to be a natural defense mechanism. Workplace Institute of Macromolecular Chemistry Contact Eva Čechová, cechova@imc.cas.cz ; Tel.: 296 809 358 Year of Publishing 2011
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