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P-body loss is concomitant with formation of a messenger RNA storage domain in mouse oocytes
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SYSNO ASEP 0346838 Document Type J - Journal Article R&D Document Type Journal Article Subsidiary J Článek ve WOS Title P-body loss is concomitant with formation of a messenger RNA storage domain in mouse oocytes Author(s) Flemr, Matyáš (UMG-J)
Ma, J. (US)
Schultz, R. M. (US)
Svoboda, Petr (UMG-J) RIDSource Title Biology of Reproduction. - : Oxford University Press - ISSN 0006-3363
Roč. 82, č. 5 (2010), s. 1008-1017Number of pages 10 s. Language eng - English Country US - United States Keywords oocyte ; mRNA ; cortex Subject RIV EB - Genetics ; Molecular Biology R&D Projects ME09039 GA MŠMT - Ministry of Education, Youth and Sports (MEYS) CEZ AV0Z50520514 - UMG-J (2005-2011) UT WOS 000276867800023 DOI 10.1095/biolreprod.109.082057 Annotation P-bodies are centers of mRNA metabolism, where meet pathways linked to mRNA silencing and degradation. So far, P-bodies were found in all examined mammalian cells.Here, we show an unexpected and important discovery that P-bodies disappear from oocztes at the beginning of their growth phase and appear again only in the early embryo. P-body decay likely reflects the requirement stabiliyation and storage of maternal mRNAs, which will govern development until the zygotc expression takes over. In addition, we were the first to show that stored maternal mRNAs do not have a homogeneous distribution. Instead, they localize to the periphery – cortex. Workplace Institute of Molecular Genetics Contact Nikol Škňouřilová, nikol.sknourilova@img.cas.cz, Tel.: 241 063 217 Year of Publishing 2011
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