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The novel mouse Polo-like kinase 5 responds to DNA damage and localizes in the nucleolus
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SYSNO ASEP 0346801 Document Type J - Journal Article R&D Document Type Journal Article Subsidiary J Článek ve WOS Title The novel mouse Polo-like kinase 5 responds to DNA damage and localizes in the nucleolus Author(s) Andrysík, Zdeněk (BFU-R)
Bernstein, W.Z. (US)
Deng, L. (US)
Myer, D.L. (US)
Li, Y.-Q. (US)
Tischfield, J.A. (US)
Stambrook, P.J. (US)
Bahassi, E.M. (US)Number of authors 8 Source Title Nucleic Acids Research. - : Oxford University Press - ISSN 0305-1048
Roč. 38, č. 9 (2010), s. 2931-2943Number of pages 13 s. Language eng - English Country GB - United Kingdom Keywords Polo ; DNA damage ; Plk5 Subject RIV BO - Biophysics CEZ AV0Z50040507 - BFU-R (2005-2011) AV0Z50040702 - BFU-R (2007-2013) UT WOS 000277994600022 DOI 10.1093/nar/gkq011 Annotation Here, we report the cloning of a fifth member of the Polo-like kinase family named Plk5. We show that mouse Plk5 is a DNA damage inducible gene. Ectopic expression of Plk5 leads to cell cycle arrest in G1, decreased DNA synthesis, and to apoptosis. Interestingly, in contrast to mouse Plk5 gene, the sequence of human Plk5 contains a stop codon that produces a truncated protein lacking part of the kinase domain. Workplace Institute of Biophysics Contact Jana Poláková, polakova@ibp.cz, Tel.: 541 517 244 Year of Publishing 2011
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