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Immunoregulatory properties of mouse limbal stem cells
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SYSNO ASEP 0346785 Document Type J - Journal Article R&D Document Type Journal Article Subsidiary J Článek ve WOS Title Immunoregulatory properties of mouse limbal stem cells Author(s) Holáň, Vladimír (UMG-J)
Pokorná, Kateřina (UMG-J)
Procházková, Jana (UMG-J)
Krulová, M. (CZ)
Zajícová, Alena (UMG-J)Source Title Journal of Immunology. - : American Association of Immunologists - ISSN 0022-1767
Roč. 184, č. 4 (2010), s. 2124-2129Number of pages 6 s. Language eng - English Country US - United States Keywords Limbal stem cells ; immunoregulation ; apoptosis Subject RIV EB - Genetics ; Molecular Biology R&D Projects KAN200520804 GA AV ČR - Academy of Sciences of the Czech Republic (AV ČR) 1M0506 GA MŠMT - Ministry of Education, Youth and Sports (MEYS) GD310/08/H077 GA ČR - Czech Science Foundation (CSF) CEZ AV0Z50520514 - UMG-J (2005-2011) UT WOS 000274585100047 DOI 10.4049/jimmunol.0903049 Annotation We isolated a highly purified population of mouse limbal stem cells. These cells expressed immunosuppressive and immunoregulatory properties. In addition, limbal stem cells had a high expression of genes for the anti-apoptotic molecules Bcl-1, XIAP and Survivin and for Fas ligand, and displayed an enhanced resistence to the apoptosis-inducing agents and to cell-mediated immunity. The results thus showed novel undescribed properties of adult stem cells. These immunoregulatory and self-protecting properties of adult tissue specific stem cells can be responsible for protection of stem cells which have a vital role in reparation and regeneration of tissues and organs. Workplace Institute of Molecular Genetics Contact Nikol Škňouřilová, nikol.sknourilova@img.cas.cz, Tel.: 241 063 217 Year of Publishing 2011
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