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MMP19 is upregulated during melanoma progression and increases invasion of melanoma cells
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SYSNO ASEP 0346783 Document Type J - Journal Article R&D Document Type Journal Article Subsidiary J Článek ve WOS Title MMP19 is upregulated during melanoma progression and increases invasion of melanoma cells Author(s) Muller, M. (DE)
Beck, Inken (UMG-J) RID
Gadesmann, J. (DE)
Karschuk, N. (DE)
Paschen, A. (DE)
Proksch, E. (DE)
Djonov, V. (CH)
Reiss, K. (DE)
Sedláček, Radislav (UMG-J) RIDSource Title Modern Pathology - ISSN 0893-3952
Roč. 23, č. 4 (2010), s. 511-521Number of pages 11 s. Language eng - English Country US - United States Keywords melanoma ; invasion ; matrix metalloproteinase Subject RIV EB - Genetics ; Molecular Biology CEZ AV0Z50520514 - UMG-J (2005-2011) UT WOS 000276197100003 DOI 10.1038/modpathol.2009.183 Annotation In this study, we analysed the expression of MMP19 in the course of melanoma progression. Although MMP19 was absent in melanocytes and melanoma cells of early stages of melanoma development, its expression was strongly upregulated in the neighbouring keratinocytes. In contrast to early stages, MMP19 was upregulated during the vertical growth phase of melanoma and in metastases. The upregulation of MMP19 in melanoma of Clark levels IV and V correlates with that of MMP2 and E-cadherin. Melanoma cell lines with low expression of MMP19 exhibited increased adhesion to various substrates and lower migration in comparison with the cell line with higher expression of MMP19. Moreover, ectopic expression of MMP19 could restore the migratory capacity of melanoma cells with low endogenous level of MMP19. These results suggest that the increase of MMP19 expression hallmarks the progression of cutaneous melanoma and might augment melanoma growth by promoting the invasion of tumour cells. Workplace Institute of Molecular Genetics Contact Nikol Škňouřilová, nikol.sknourilova@img.cas.cz, Tel.: 241 063 217 Year of Publishing 2011
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