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Matrix metalloproteinase-19 is highly expressed in astroglial tumors and promotes invasion of glioma cells
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SYSNO ASEP 0346779 Document Type J - Journal Article R&D Document Type Journal Article Subsidiary J Článek ve WOS Title Matrix metalloproteinase-19 is highly expressed in astroglial tumors and promotes invasion of glioma cells Author(s) Lettau, I. (DE)
Hattermann, K. (DE)
Held-Feindt, J. (DE)
Brauer, Rena (UMG-J)
Sedláček, Radislav (UMG-J) RID
Mentlein, R. (DE)Source Title Journal of Neuropathology and Experimental Neurology - ISSN 0022-3069
Roč. 69, č. 3 (2010), s. 215-223Number of pages 9 s. Language eng - English Country US - United States Keywords extracellular matrix ; MMP-28 ; keratinocytes Subject RIV EB - Genetics ; Molecular Biology CEZ AV0Z50520514 - UMG-J (2005-2011) UT WOS 000275418600001 DOI 10.1097/NEN.0b013e3181ce9f67 Annotation Glial tumors exhibit a high morbidity and mortality because of their invasive nature. Matrix metalloproteinase 19 (MMP19) is a secreted protease that together with epilysin (MMP28) forms a structural subgroup of MMPs. In contrast, MMP19 was detected in normal brain samples only in endothelial cells but was found at high levels in astrocytomas. MMP19 was upregulated in GB cells after exposure to proinflammatory cytokines. MMP19-silenced cells migrated more slowly through laminin-, basal lamina-, and brevican-coated membranes than controls. MMP19-silenced GB cells also migrated into brain tissue slices compared with control cells. Brevican, a brain-specific proteoglycan and major component of brain extracellular matrix, was degraded by recombinant human MMP19. MMP19 is highly expressed in proliferating astrocytoma/glioma cells and its expression may facilitate their invasion through brain extracellular matrix Workplace Institute of Molecular Genetics Contact Nikol Škňouřilová, nikol.sknourilova@img.cas.cz, Tel.: 241 063 217 Year of Publishing 2011
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