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Efficacy of S-adenosylhomocysteine hydrolase inhibitors, D-eritadenine and (S)-DHPA, against the growth of Cryptosporidium parvum in vitro
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SYSNO ASEP 0346777 Document Type J - Journal Article R&D Document Type Journal Article Subsidiary J Článek ve WOS Title Efficacy of S-adenosylhomocysteine hydrolase inhibitors, D-eritadenine and (S)-DHPA, against the growth of Cryptosporidium parvum in vitro Author(s) Čtrnáctá, Vlasta (BTO-N) RID
Fritzler, J. M. (US)
Šurínová, M. (CZ)
Hrdý, I. (CZ)
Zhu, G. (US)
Stejskal, F. (CZ)Source Title Experimental Parasitology. - : Elsevier - ISSN 0014-4894
Roč. 126, č. 2 (2010), s. 113-116Number of pages 4 s. Language eng - English Country US - United States Keywords S-adenosylhomocysteine hydrolase ; D-eritadenine ; (S)-DHPA Subject RIV EB - Genetics ; Molecular Biology CEZ AV0Z50520701 - BTO-N (2007-2013) UT WOS 000280885500001 DOI 10.1016/j.exppara.2010.04.007 Annotation D-eritadenine and (S)-DHPA are aliphatic adenosine analogues known to target S-adenosylhomocysteine hydrolase (SAHH) and potent antiviral compounds. In the present study, we demonstrate that these two compounds also display efficacy against recombinant SAHH enzyme of the protozoan parasite Cryptosporidium parvum, as well as inhibition of parasite growth in vitro. Our data confirm that SAHH could serve as a rational drug target in cryptosporidial infection and antiviral adenosine analogues are potential candidates for drug development against cryptosporidiosis Workplace Institute of Biotechnology Contact Monika Kopřivová, Monika.Koprivova@ibt.cas.cz, Tel.: 325 873 700 Year of Publishing 2011
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